University of Pennsylvania's Tissue Microarrays (TMAs)
The University of Pennsylvania Datasheet are available for download. University of Pennsylvania Datasheet file
The University of Pennsylvania XML file are available for download. University of Pennsylvania XML file
NOTE: You will need the Image Scope application to view the Whole Slide Images.
TMA 1
The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 10 patients have been incorporated: 4 patients have tissue cores from the primary lesion only, 5 patients have tissue cores from the primary lesion and normal tissue, and 1 patient has tissue cores from the normal tissue, primary and metastatic lesions. Of the patients with available clinical annotation, 60% are male and 40% are female, and racial breakdown is as follows: 100% white. Pathologic site and histologic type for annotated cases is below:
| Site | ||
| Peritoneum | 0% | |
| Pleura | 80% | Right 50% |
| Left 37.5% | ||
| Not Specified | 12.5% | |
| Not Specified | 0% | |
| Other | 20% | |
| Unknown | 0% | |
| Skin | 0% | |
| Histologic Type | |
| Biphasic | 0% |
| Epithelial/Epithelioid | 90% |
| Sarcomatoid | 10% |
| Multicystic | 0% |
| Papillary | 0% |
| Other | 0% |
| Not specified | 0% |
Click here to download University of Pennsylvania TMA-1 Map Microsoft Excel file
Click here to download University of Pennsylvania TMA-1 Whole Slide Image
TMA 2
The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 12 patients have been incorporated: 4 patients have tissue cores from the primary lesion only, 2 patient has tissue cores from normal tissue only, 4 patients have tissue cores from the primary lesion and normal tissue, 1 patient has tissue cores from normal tissue, primary and metastatic lesions, and 1 patient has tissue cores from both the primary and metastatic lesions. Of the patients with available clinical annotation, 91.6% are male and 8.3% are female, and racial breakdown is as follows: 100% white. Pathologic site and histologic type for annotated cases is below:
| Site | ||
| Peritoneum | 8.3% | |
| Pleura | 91.6% | Right 63.3% |
| Left 9.09% | ||
| Not Specified | 27.27% | |
| Not Specified | 0% | |
| Other | 0% | |
| Unknown | 0% | |
| Skin | 0% | |
| Histologic Type | |
| Biphasic | 33.3% |
| Epithelial/Epithelioid | 50% |
| Sarcomatoid | 16.6% |
| Multicystic | 0% |
| Papillary | 0% |
| Other | 0% |
| Not specified | 0% |
Click here to download University of Pennsylvania TMA-2 Map Microsoft Excel file
Click here to download University of Pennsylvania TMA-2 Whole Slide Image
TMA 3
The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 9 patients have been incorporated: 4 patients have tissue cores from the primary lesion only, and 5 patients have tissue cores from normal tissue and primary lesions. Of the patients with available clinical annotation, 88.8% are male and 11.1% are female, and racial breakdown is as follows: 88.8% white, and 11.1% black. Pathologic site and histologic type for annotated cases is below:
| Site | ||
| Peritoneum | 11.1% | |
| Pleura | 77.7% | Right 57.1% |
| Left 28.5% | ||
| Not Specified 14.2% | ||
| Not Specified | 0% | |
| Other | 11.1% | |
| Unknown | 0% | |
| Skin | 0% | |
| Histologic Type | |
| Biphasic | 11.1% |
| Epithelial/Epithelioid | 77.7% |
| Sarcomatoid | 0% |
| Multicystic | 0% |
| Papillary | 0% |
| Other | 11.1% |
| Not specified | 0% |
Click here to download University of Pennsylvania TMA-3 Map Microsoft Excel file
Click here to download University of Pennsylvania TMA-3 Whole Slide Image
TMA 4
The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 30 patients have been incorporated: 15 patients have tissue cores from the primary lesion only, 7 patients have tissue cores from normal tissue only, 1 patient has tissue cores from the metastatic lesion only, 6 patients have tissue cores from normal tissue and primary lesions, and 1 patient has tissue cores from both the primary and metastatic lesions. Of the patients with available clinical annotation, 83.3% are male and 16.6% are female, and racial breakdown is as follows: 86.6% white, 3.3% black, and 10% unknown. Pathologic site and histologic type for annotated cases is below:
| Site | ||
| Peritoneum | 10% | |
| Pleura | 90% | Right 48.1% |
| Left 22.2% | ||
| Not Specified 25.9% | ||
| Not Specified | 0% | |
| Other | 0% | |
| Unknown | 0% | |
| Skin | 0% | |
| Histologic Type | |
| Biphasic | 13.3% |
| Epithelial/Epithelioid | 73.3% |
| Sarcomatoid | 13.3% |
| Multicystic | 0% |
| Papillary | 0% |
| Other | 0% |
| Not specified | 0% |
Click here to download University of Pennsylvania TMA-4 Map Microsoft Excel file
Click here to download University of Pennsylvania TMA-4 Whole Slide Image