Tissue Microarrays (TMAs)

TMA 1

The TMA has been designed to facilitate identification of markers differentially expressed in primary mesothelioma lesions as well as metastatic lesions. Samples from 40 patients have been incorporated: 36 patients have tissue cores from the primary lesion only, 3 patients have tissue cores from a metastatic lesion only, and 1 patient has tissue cores from both the primary and metastatic lesions. Of the patients with available clinical annotation, 97% are male and 3% are female, and racial breakdown is as follows: 57% white, 3% black, and 39% unknown. Pathologic site and histologic type for annotated cases is below:

Site
Peritoneum 25%
Pleura 47.5% Right 79 %
Left 21 %
Not Specified 5%
Other 15%
Unknown 5%
Skin 2.5%
Histologic Type
Biphasic 32 %
Epithelial/Epithelioid 26 %
Sarcomatoid 9 %
Multicystic 3 %
Papillary 3 %
Other 15 %
Not specified 12 %

TMA 1 Layout

Click on an NMVB number to view its annotated data. The slide information will appear in a new window.

       Slide positions in red are metastatic tumors.
       Slide positions in yellow are mixed metastatic and primary tumors.
       Slide positions in green are primary tumors.

The Core Array map and XML file are available for download.

University of Pittsburgh TMA-1 Whole Slide Image are available for download.

NOTE: You will need the Image Scope application to view the Whole Slide Images.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
A 33 37 38 38 39   366 32 366   33 37 38 38 39 57
B 40 41 44 45 51   49 236 62   40 41 44 45 51 48
C 54 55 59 361 67   65 70 79   54 55 59 361 67 53
D 73 75 76 226 230   232 234 231   73 75 76 226 230 56
E 231 233 359 360 61   368 41 368   231 233 359 360 61 60
F                                
G 33 37 38 38 39   366 32 366   33 37 38 38 39  
H 40 41 44 45 51   49 236 62   40 41 44 45 51  
I 54 55 59 361 67   65 70 79   54 55 59 361 67  
J 73 75 76 226 230   232 234 236   73 75 76 226 230  
K 231 233 359 360 61   368 41 368   231 233 359 360 61  
MVB ID Block Age at Dx Invasive Histological Type Vital Status
MVB 32 1A 41-50 Epithelial or epithelioid Dead
MVB 33 2E 61-70 Epithelial or epithelioid Dead
MVB 37 3AFS 71-80 Biphasic Dead
MVB 38 4D 51-60 Epithelial or epithelioid Dead
MVB 39 5G 51-60 Epithelial or epithelioid Dead
MVB 40 11A 61-70 Epithelial or epithelioid Alive
MVB 40 1B 61-70 Epithelial or epithelioid Alive
MVB 41 1M 61-70 Papillary Dead
MVB 44 1D Unknown Epithelial or epithelioid Alive
MVB 45 1C 51-60 Epithelial or epithelioid Dead
MVB 48 2A 71-80 Biphasic Dead
MVB 49 3B 71-80 Sarcomatoid Dead
MVB 51 B 41-50 Biphasic Dead
MVB 51 C 41-50 Biphasic Dead
MVB 53 2L 71-80 Biphasic Dead
MVB 54 1H 61-70 Epithelial or epithelioid alive
MVB 55 2C 61-70 Epithelial or epithelioid Dead
MVB 56 2C 31-40 Epithelial or epithelioid Alive
MVB 57 1B 71-80 Biphasic Dead
MVB 59 2B 31-40 Papillary Alive
MVB 60 1B Unknown Multicystic Unknown
MVB 61 3I 71-80 Sarcomatoid Dead
MVB 62 3A Unknown Epithelial or epithelioid Dead
MVB 65 2B 71-80 Other Dead
MVB 67 D Unknown Not Specified  
MVB 70 2A Unknown Epithelial or epithelioid Unknown
MVB 73 A Unknown Epithelial or epithelioid Unknown
MVB 75 3C Unknown Biphasic Unknown
MVB 76 1C 51-60 Biphasic Dead
MVB 79 H Unknown Sarcomatoid Unknown
MVB 226 5B Unknown Desmoplastic Unknown
MVB 230 A Unknown Other Unknown
MVB 231 2A Unknown Other Unknown
MVB 231 2B   Other  
MVB 232 3 Unknown Not Specified Unknown
MVB 233 B Unknown Not Specified Unknown
MVB 234 1FS Unknown Not Specified Unknown
MVB 236 1 Unknown Epithelial or epithelioid Unknown
MVB 359 1A 81-90 Epithelial or epithelioid Unknown
MVB 359 1C 81-90 Epithelial or epithelioid Unknown
MVB 360 5H 61-70 Epithelial or epithelioid Unknown
MVB 361 1C 61-70 Epithelial or epithelioid Unknown
MVB 366 1B 61-70 Epithelial or epithelioid Unknown
MVB 366 2A 61-70 Epithelial or epithelioid Unknown
MVB 368 #1 51-60 Biphasic Unknown
MVB 368 #2 51-60 Biphasic Unknown